Semaphorin-3A inhibits multiple myeloma progression in a mouse model
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چکیده
منابع مشابه
Systemic and targeted delivery of semaphorin 3A inhibits tumor angiogenesis and progression in mouse tumor models.
OBJECTIVE The role of semaphorins in tumor progression is still poorly understood. In this study, we aimed at elucidating the regulatory role of semaphorin 3A (SEMA3A) in primary tumor growth and metastatic dissemination. METHODS AND RESULTS We used 3 different experimental approaches in mouse tumor models: (1) overexpression of SEMA3A in tumor cells, (2) systemic expression of SEMA3A followi...
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Introduction: Semaphorin 3A (Sema 3A) is a secreted protein, which plays an integral part in developing the nervous system. It has collapse activity on the growth cone of dorsal root ganglia. After the development of the nervous system, Sema 3A expression decreases. Neuropilin 1 is a membrane receptor of Sema 3A. When semaphorin binds to neuropilin 1, the recruitment of oligodendrocyte precurso...
متن کاملMeningeal cell-derived semaphorin 3A inhibits neurite outgrowth.
The neural scar that forms after injury to the mammalian central nervous system is a barrier to sprouting and regenerating axons. In addition to reactive astrocytes that are present throughout the lesion site, leptomeningeal fibroblasts invade the lesion core. When isolated in vitro, these cells form a very poor substrate for growing neurites, even more so than reactive astrocytes. Nevertheless...
متن کاملLoss of inhibitory semaphorin 3A (SEMA3A) autocrine loops in bone marrow endothelial cells of patients with multiple myeloma.
Vascular endothelial growth factor165 (VEGF165) and semaphorin3A (SEMA3A) elicit pro- and antiangiogenic signals respectively in endothelial cells (ECs) by binding to their receptors VEGFR-2, neuropilin-1 (NRP1), and plexin-A1. Here we show that the VEGF165-driven angiogenic potential of multiple myeloma (MM) ECs is significantly higher than that of monoclonal gammopathy of undetermined signifi...
متن کاملIntegrative Physiology and Experimental Medicine Systemic and Targeted Delivery of Semaphorin 3A Inhibits Tumor Angiogenesis and Progression in Mouse Tumor Models
Larsson, Peter Carmeliet, Michele De Palma, Luigi Naldini, Luca Tamagnone and Charlotte Giustacchini, Mario Leonardo Squadrito, Mary Anna Venneri, Massimiliano Mazzone, Erik Andrea Casazza, Xi Fu, Irja Johansson, Lorena Capparuccia, Fredrik Andersson, Alice Progression in Mouse Tumor Models Systemic and Targeted Delivery of Semaphorin 3A Inhibits Tumor Angiogenesis and Print ISSN: 1079-5642. On...
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ژورنال
عنوان ژورنال: Carcinogenesis
سال: 2018
ISSN: 0143-3334,1460-2180
DOI: 10.1093/carcin/bgy106